[{"data":1,"prerenderedAt":244},["ShallowReactive",2],{"compound-ipamorelin":3,"compound-related-ipamorelin":221,"compound-reading-ipamorelin":236},{"id":4,"title":5,"alsoKnownAs":6,"body":7,"casNumber":60,"category":193,"description":183,"extension":194,"faq":195,"meta":202,"molecularFormula":76,"molecularWeight":84,"name":5,"navigation":203,"path":204,"presentations":205,"purity":208,"rank":209,"relatedCompounds":210,"relatedResearch":213,"seo":216,"sequence":217,"stem":218,"summary":219,"__hash__":220},"compounds\u002Fcompounds\u002Fipamorelin.md","Ipamorelin","NNC 26-0161",{"type":8,"value":9,"toc":182},"minimark",[10,15,19,22,26,101,105,108,135,138,142,145,148,152,155,168,172,175,179],[11,12,14],"h2",{"id":13},"what-ipamorelin-is","What ipamorelin is",[16,17,18],"p",{},"Ipamorelin is a synthetic pentapeptide that acts as a selective agonist at the\ngrowth hormone secretagogue receptor (GHS-R1a), the receptor for endogenous\nghrelin. Its sequence — Aib-His-D-2-Nal-D-Phe-Lys-NH₂ — contains three\nnon-proteinogenic residues and a C-terminal amide, and at roughly 712 Da it is\none of the smallest peptides in routine research use.",[16,20,21],{},"Its defining property is selectivity. The first generation of growth hormone\nsecretagogues activated GHS-R1a but carried a substantial off-target profile:\nappetite signalling, cortisol, prolactin. Ipamorelin was developed specifically\nto separate the growth hormone secretagogue activity from that profile, and its\ncontinued use as a research tool follows from that separation.",[11,23,25],{"id":24},"molecular-profile","Molecular profile",[27,28,29,42],"table",{},[30,31,32],"thead",{},[33,34,35,39],"tr",{},[36,37,38],"th",{},"Property",[36,40,41],{},"Value",[43,44,45,53,61,69,77,85,93],"tbody",{},[33,46,47,51],{},[48,49,50],"td",{},"Development code",[48,52,6],{},[33,54,55,58],{},[48,56,57],{},"CAS number",[48,59,60],{},"170851-70-4",[33,62,63,66],{},[48,64,65],{},"Sequence",[48,67,68],{},"Aib-His-D-2-Nal-D-Phe-Lys-NH₂",[33,70,71,74],{},[48,72,73],{},"Molecular formula",[48,75,76],{},"C38H49N9O5",[33,78,79,82],{},[48,80,81],{},"Molecular weight",[48,83,84],{},"~711.9 Da",[33,86,87,90],{},[48,88,89],{},"Receptor target",[48,91,92],{},"GHS-R1a (ghrelin receptor)",[33,94,95,98],{},[48,96,97],{},"Appearance",[48,99,100],{},"White lyophilised powder",[11,102,104],{"id":103},"non-standard-residues-and-why-they-are-there","Non-standard residues and why they are there",[16,106,107],{},"Three of the five residues are unusual, and each is doing specific work:",[109,110,111,119,129],"ul",{},[112,113,114,118],"li",{},[115,116,117],"strong",{},"Aib (2-aminoisobutyric acid)"," — a doubly methylated alanine that constrains\nbackbone conformation, favouring the shape the receptor recognises.",[112,120,121,124,125,128],{},[115,122,123],{},"D-2-naphthylalanine"," and ",[115,126,127],{},"D-phenylalanine"," — D-configuration amino acids\nthat proteases evolved on L-peptides do not efficiently cleave.",[112,130,131,134],{},[115,132,133],{},"C-terminal amide"," — removes the free carboxyl terminus, closing off\ncarboxypeptidase degradation.",[16,136,137],{},"A five-residue L-peptide would be degraded almost immediately. These\nmodifications are what make a molecule this small viable at all.",[11,139,141],{"id":140},"research-context","Research context",[16,143,144],{},"Ipamorelin is used in growth hormone axis research as a selective GHS-R1a probe:\nreceptor binding and selectivity assays, calcium mobilisation and inositol\nphosphate accumulation as functional readouts, and pituitary cell models\nexamining growth hormone release. It is frequently paired with a GHRH receptor\nagonist such as CJC-1295, since the two engage different receptors within the\nsame regulatory axis, allowing the contributions to be separated.",[16,146,147],{},"Supplied for in-vitro laboratory research only. No therapeutic claim is made and\nno dosing or administration guidance is provided.",[11,149,151],{"id":150},"analytical-notes","Analytical notes",[16,153,154],{},"Ipamorelin's small size makes it comparatively straightforward to characterise —\nmass confirmation is unambiguous, and impurities separate more cleanly than they\ndo for a 40-residue peptide.",[16,156,157,158,161,162,167],{},"The analytical question that does arise is ",[115,159,160],{},"stereochemical",". Two of the five\nresidues are D-amino acids, and a synthesis that incorporates the L-form at\neither position produces a diastereomer with an identical molecular mass. Mass\nspectrometry cannot detect this. Chromatography can, because diastereomers have\ndifferent retention times — but only if the method resolves them and the analyst\nis looking. It is a good illustration of why a purity figure and an identity\nfigure together are still not the same thing as a chromatogram someone has\nexamined. See\n",[163,164,166],"a",{"href":165},"\u002Fresearch\u002Finterpreting-hplc-chromatograms","reading an HPLC chromatogram",".",[11,169,171],{"id":170},"handling-and-storage","Handling and storage",[16,173,174],{},"Store sealed at −20 °C, protected from light and moisture, and bring to room\ntemperature before opening. Reconstitute by running diluent down the vial wall\nand swirling gently. Small peptides tolerate handling better than large ones,\nbut the practice costs nothing. Store solution at 2–8 °C, protected from light.",[11,176,178],{"id":177},"what-we-supply","What we supply",[16,180,181],{},"Released against a ≥99% purity specification, with HPLC purity and mass\nspectrometry identity confirmation on every batch and a batch-specific\nCertificate of Analysis. Select batches additionally receive independent\nthird-party purity verification.",{"title":183,"searchDepth":184,"depth":184,"links":185},"",2,[186,187,188,189,190,191,192],{"id":13,"depth":184,"text":14},{"id":24,"depth":184,"text":25},{"id":103,"depth":184,"text":104},{"id":140,"depth":184,"text":141},{"id":150,"depth":184,"text":151},{"id":170,"depth":184,"text":171},{"id":177,"depth":184,"text":178},"Growth Hormone","md",[196,199],{"question":197,"answer":198},"What makes ipamorelin selective?","Earlier growth hormone secretagogues activated the ghrelin receptor but also produced marked increases in appetite signalling, cortisol and prolactin. Ipamorelin was developed to retain growth hormone secretagogue receptor activity with substantially less of that off-target profile, and that selectivity is the reason it remains a widely used research tool.",{"question":200,"answer":201},"Why does ipamorelin contain non-standard amino acids?","Aib (2-aminoisobutyric acid), D-2-naphthylalanine and D-phenylalanine are not among the twenty proteinogenic amino acids. They are used to lock conformation and to resist proteolysis — a D-amino acid is not a substrate for enzymes that evolved to cleave L-peptides. This is what allows a five-residue peptide to remain intact long enough to be useful.",{},true,"\u002Fcompounds\u002Fipamorelin",[206,207],"2 mg vial","5 mg vial","≥99%",21,[211,212],"cjc-1295","cjc-1295-ipamorelin",[214,215],"how-to-read-a-peptide-coa","interpreting-hplc-chromatograms",{"title":5,"description":183},"Aib-His-D-2-Nal-D-Phe-Lys-NH2","compounds\u002Fipamorelin","A selective growth hormone secretagogue receptor agonist, notable for acting on the ghrelin receptor without the appetite and cortisol effects of earlier secretagogues.","VXKwZGOdAOlkvYsFFOeT6RSwRRzDsTCiMjGXlkaO-oE",[222,228],{"path":223,"name":224,"alsoKnownAs":225,"summary":226,"category":193,"molecularWeight":227,"purity":208},"\u002Fcompounds\u002Fcjc-1295","CJC-1295","Modified GRF (1-29) · CJC-1295 without DAC","A modified growth hormone-releasing hormone analogue, engineered for resistance to enzymatic cleavage while retaining a short pulsatile signal.","~3,368 Da",{"path":229,"name":230,"alsoKnownAs":231,"summary":232,"category":233,"molecularWeight":234,"purity":235},"\u002Fcompounds\u002Fcjc-1295-ipamorelin","CJC-1295 + Ipamorelin","GH axis blend","A combined preparation of Modified GRF (1-29) and ipamorelin, pairing a GHRH receptor agonist with a selective ghrelin receptor agonist.","Blends",null,"≥99% per component",[237,241],{"path":238,"title":239,"description":240},"\u002Fresearch\u002Fhow-to-read-a-peptide-coa","How to Read a Peptide Certificate of Analysis","A field-by-field walkthrough of a peptide COA — what each number establishes, which fields are load-bearing, and what a missing batch number tells you about the rest of the document.",{"path":165,"title":242,"description":243},"Reading an HPLC Chromatogram: What the Trace Shows That the Percentage Doesn't","A purity figure is one number extracted from a picture. How to read the picture — baseline, peak shape, resolution, where the impurities sit, and what an integration boundary can hide.",1787473952836]