[{"data":1,"prerenderedAt":253},["ShallowReactive",2],{"compound-bpc-157":3,"compound-related-bpc-157":225,"compound-reading-bpc-157":240},{"id":4,"title":5,"alsoKnownAs":6,"body":7,"casNumber":69,"category":193,"description":184,"extension":194,"faq":195,"meta":205,"molecularFormula":77,"molecularWeight":85,"name":5,"navigation":206,"path":207,"presentations":208,"purity":211,"rank":212,"relatedCompounds":213,"relatedResearch":216,"seo":220,"sequence":221,"stem":222,"summary":223,"__hash__":224},"compounds\u002Fcompounds\u002Fbpc-157.md","BPC-157","Body Protection Compound 157 · PL 14736",{"type":8,"value":9,"toc":183},"minimark",[10,15,19,22,26,102,106,109,138,141,144,148,151,157,169,173,176,180],[11,12,14],"h2",{"id":13},"what-bpc-157-is","What BPC-157 is",[16,17,18],"p",{},"BPC-157 is a synthetic pentadecapeptide — fifteen amino acids — corresponding to\na partial sequence of Body Protection Compound, a protein isolated from human\ngastric juice. Its sequence is\nGly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, notable for a\nproline-rich stretch that contributes to its conformational rigidity and to its\nreported stability.",[16,20,21],{},"That stability is the compound's most distinctive physical property. Short\npeptides are generally fragile in proteolytic environments; BPC-157 is reported\nto remain intact in human gastric juice, which is unusual enough to have driven\nmuch of the early interest in it.",[11,23,25],{"id":24},"molecular-profile","Molecular profile",[27,28,29,42],"table",{},[30,31,32],"thead",{},[33,34,35,39],"tr",{},[36,37,38],"th",{},"Property",[36,40,41],{},"Value",[43,44,45,54,62,70,78,86,94],"tbody",{},[33,46,47,51],{},[48,49,50],"td",{},"Sequence",[48,52,53],{},"GEPPPGKPADDAGLV",[33,55,56,59],{},[48,57,58],{},"Length",[48,60,61],{},"15 amino acids",[33,63,64,67],{},[48,65,66],{},"CAS number",[48,68,69],{},"137525-51-0",[33,71,72,75],{},[48,73,74],{},"Molecular formula",[48,76,77],{},"C62H98N16O22",[33,79,80,83],{},[48,81,82],{},"Molecular weight",[48,84,85],{},"~1,419.5 Da",[33,87,88,91],{},[48,89,90],{},"Common salt form",[48,92,93],{},"Acetate",[33,95,96,99],{},[48,97,98],{},"Appearance",[48,100,101],{},"White lyophilised powder",[11,103,105],{"id":104},"research-context","Research context",[16,107,108],{},"The BPC-157 literature is largely preclinical and concentrated in tissue repair\nmodels. Reported lines of investigation include:",[110,111,112,120,126,132],"ul",{},[113,114,115,119],"li",{},[116,117,118],"strong",{},"Angiogenesis"," — effects on endothelial cell migration and tube formation in\nvitro, with reported involvement of VEGF receptor 2 signalling.",[113,121,122,125],{},[116,123,124],{},"Tendon and ligament models"," — fibroblast migration, adhesion and survival in\ncultured tendon explants.",[113,127,128,131],{},[116,129,130],{},"Gastrointestinal models"," — mucosal integrity in experimental injury.",[113,133,134,137],{},[116,135,136],{},"Nitric oxide pathway interaction"," — a recurring theme across the literature,\nwith reported modulation of NO system activity.",[16,139,140],{},"The evidence base is dominated by rodent work from a relatively small number of\nresearch groups, and human clinical data is limited. That is a genuine\ncharacterisation of the literature rather than a caveat added for form.",[16,142,143],{},"Supplied for in-vitro laboratory research only. No therapeutic claim is made and\nno dosing or administration guidance is provided.",[11,145,147],{"id":146},"analytical-notes","Analytical notes",[16,149,150],{},"At 15 residues BPC-157 is a comparatively straightforward peptide to synthesise\nand to characterise, which means the analytical questions are about the\nmanufacturing rather than about the method.",[16,152,153,156],{},[116,154,155],{},"Deletion sequences"," are the impurity class of interest. A synthesis that fails\nto couple one residue produces a 14-mer differing by a single amino acid — close\nenough in retention time that a lazily integrated chromatogram can absorb it into\nthe main peak, and different enough in mass that mass spectrometry catches it\nimmediately.",[16,158,159,162,163,168],{},[116,160,161],{},"Salt form changes what the label means."," Acetate and arginate salts of the\nsame peptide carry different counter-ion masses, so 10 mg of gross material is a\ndifferent quantity of peptide depending on which you have. The certificate should\nstate the salt form and, ideally, the net peptide content —\n",[164,165,167],"a",{"href":166},"\u002Fresearch\u002Fnet-peptide-content-vs-purity","the difference between net peptide content and purity","\nis where most concentration errors originate.",[11,170,172],{"id":171},"handling-and-storage","Handling and storage",[16,174,175],{},"Store sealed at −20 °C, protected from light and moisture. Allow the vial to\nreach room temperature before opening. BPC-157 is more forgiving to reconstitute\nthan the lipidated metabolic peptides, but the same practice applies: run diluent\ndown the vial wall, swirl rather than shake, and store the resulting solution at\n2–8 °C protected from light.",[11,177,179],{"id":178},"what-we-supply","What we supply",[16,181,182],{},"Released against a ≥99% purity specification, with in-house HPLC and mass\nspectrometry on every batch and a batch-specific Certificate of Analysis\nrecording the salt form as well as the purity. Select batches additionally\nreceive independent third-party purity verification.",{"title":184,"searchDepth":185,"depth":185,"links":186},"",2,[187,188,189,190,191,192],{"id":13,"depth":185,"text":14},{"id":24,"depth":185,"text":25},{"id":104,"depth":185,"text":105},{"id":146,"depth":185,"text":147},{"id":171,"depth":185,"text":172},{"id":178,"depth":185,"text":179},"Repair & Recovery","md",[196,199,202],{"question":197,"answer":198},"What is BPC-157 studied for?","Published research examines BPC-157 in tissue repair models — tendon, ligament, muscle and gastrointestinal mucosa — with reported effects on fibroblast migration, angiogenesis and growth factor receptor expression. The large majority of this literature is preclinical, predominantly rodent, and Tested Peptides supplies the compound for in-vitro laboratory research only.",{"question":200,"answer":201},"Is BPC-157 a stable peptide?","Unusually so for its size. It is reported to be stable in human gastric juice, which is atypical for a short peptide and is one reason it has attracted research interest. As a lyophilised powder it is robust at appropriate storage temperatures, and it is less prone to interfacial aggregation than the fatty-acid-conjugated metabolic peptides.",{"question":203,"answer":204},"What is the difference between BPC-157 and its arginate salt form?","BPC-157 is commonly supplied as an acetate salt. Some material is supplied as an arginate salt, which alters the counter-ion and therefore the gross vial mass for a given quantity of peptide, without changing the peptide itself. The Certificate of Analysis should state the salt form, because it changes what the label mass means.",{},true,"\u002Fcompounds\u002Fbpc-157",[209,210],"5 mg vial","10 mg vial","≥99%",10,[214,215],"tb-500","bpc-tb-500",[217,218,219],"how-to-read-a-peptide-coa","peptide-aggregation-and-handling","interpreting-hplc-chromatograms",{"title":5,"description":184},"Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val","compounds\u002Fbpc-157","A synthetic 15-amino-acid sequence derived from human gastric juice protein BPC, studied extensively in tissue repair and angiogenesis models.","xYU1gRxek19K1xX73xdqjicW-sRgJw2ezjlXh45sjwE",[226,234],{"path":227,"name":228,"alsoKnownAs":229,"summary":230,"category":231,"molecularWeight":232,"purity":233},"\u002Fcompounds\u002Fbpc-tb-500","BPC-157 + TB-500","Repair blend","A combined preparation of BPC-157 and thymosin β4, used where both compounds are required in a single reconstitution.","Blends",null,"≥99% per component",{"path":235,"name":236,"alsoKnownAs":237,"summary":238,"category":193,"molecularWeight":239,"purity":211},"\u002Fcompounds\u002Ftb-500","TB-500","Thymosin β4 · Tβ4","A synthetic form of thymosin beta-4, the principal actin-sequestering peptide in mammalian cells, studied in cell migration and tissue repair models.","~4,963 Da",[241,245,249],{"path":242,"title":243,"description":244},"\u002Fresearch\u002Fhow-to-read-a-peptide-coa","How to Read a Peptide Certificate of Analysis","A field-by-field walkthrough of a peptide COA — what each number establishes, which fields are load-bearing, and what a missing batch number tells you about the rest of the document.",{"path":246,"title":247,"description":248},"\u002Fresearch\u002Finterpreting-hplc-chromatograms","Reading an HPLC Chromatogram: What the Trace Shows That the Percentage Doesn't","A purity figure is one number extracted from a picture. How to read the picture — baseline, peak shape, resolution, where the impurities sit, and what an integration boundary can hide.",{"path":250,"title":251,"description":252},"\u002Fresearch\u002Fpeptide-aggregation-and-handling","Why Peptide Solutions Go Cloudy: Aggregation and Handling","Shaking a reconstituted peptide is the most common way to ruin one. The interfacial mechanism behind aggregation, why lipidated peptides are worse, and the handling practice that follows from it.",1787473952615]